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KMID : 0363320070280010001
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 1 p.1 ~ p.11
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Effects of Astragali Radix on Neutropenia Caused by Cyclophosphamide
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Jeong Seung-Min
Ko Seong-Gyu
Go Ho-Yeon
Choi You-Kyung
Kim Dong-Woo
Park Jong-Hyung
Jeon Chan-Yong
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Abstract
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Objective : To study effects of Astragali radix on relieving neutropenia caused by cyclophosphamide.
Method : We administered Astragali radixextracts for 7 days before injecting cyclophosphamide 200mg/kg to mice subcutaneously to cause neutropenia. The control group wasn’t administered Astragali radix. One test group was administered Astragali radix extracts 500mg/kg and the other was administered 1000mg/kg. We observed WBC, neutrophil, lymphocyte, platelet, RBC, GOT, GPT, BUN, and creatine.
Result : WBC, RBC, lymphocyte, neutrophil, and platelet improved more in mice administered Astragali radix extracts. Moreover, the 1000mg/kg group was more affected than the 500mg/kg group generally. GOT, GPT, BUN, and creatine weren’t changed significantly compared with the control group.
Conclusion : It is shown that Astragali radix extracts can relieve neutropenia induced by cyclophosphamide and we conclude that Astragali radix will be useful for cancer treatment.
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KEYWORD
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Astragali Radix, Neutropenia, Cyclophosphamide
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